供应PF06463922原料药哪里有卖生产销售基地

详情描述：

PF06463922          
产品名称: PF-06463922
英文品称：PF-06463922
产品别名: 无
外观性状: 白色或类白色粉末
CAS号: 1454846-35-5
分子式: C21H19FN6O2
分子量: 406.41
纯度: 99.5%
包装: 内自封袋外铝箔, 棕色试剂瓶
规格: 1克，5克，10克，50克，100克
用途: 本产品仅供科研实验用途          
供应能力          can supply g scale
别名           PF 06463922;PF06463922
产品简述           PF-06463922 is a novel, orally available, CNS-ation. Furthermore, PF-06463922 demonstrated antitumorpenetrant, ATP-competitive inhibitor of ALK/ROS1 with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
详细说明          PF-06463922 demonstrates significant cell activity against ALK and a large set of ALK clinical mutations with IC50 ranging from 0.2 nM-77 nM. PF-06463922 exhibited subnanomolar cellular potency against oncogenic ROS1 fusions and inhibited the crizotinib-refractory ROS1(G2032R) mutation and the ROS1(G2026M) gatekeeper mutation. Compared with crizotinib and the second-generation ALK/ROS1 inhibitors ceritinib and alectinib, PF-06463922 showed significantly improved inhibitory activity against ROS1 kinase. in vivo: PF-06463922 showed marked antitumor activity in tumor models expressing FIG-ROS1, CD74-ROS1, and the CD74-ROS1(G2032R) mutation. Furthermore, PF-06463922 demonstrated antitumor activity in a genetically engineered mouse model of FIG-ROS1 glioblastoma.